Foldit

admin管理员组

文章数量:1437123

Foldit

Foldit （科学上网）

Foldit is a one-of-a-kindprotein folding computer gamedeveloped by university scientists. By playing Foldit, you can contribute to advanced research on human health, cutting-edge bioengineering, and the inner workings of biology.

Foldit 是一款由大学科学家开发的独一无二的蛋白质折叠电脑游戏。通过玩 Foldit，您可以贡献于人类健康、尖端生物工程和生物内部运作的高级研究。

Foldit isfree to playand not-for-profit. Discoveries made in the game are published in peer-reviewed research journals and Foldit players are always credited for their contributions.

Foldit 免费游玩且非营利。游戏中做出的发现将在同行评审的研究期刊上发表，Foldit 玩家总是因其贡献获得认可。

Every week, Foldit scientists post new puzzles focused on the latest problems in protein folding. Read on to learn about ongoing research inprotein designto treat diseases like influenza and COVID-19,small molecule designto invent new drug compounds, andprotein structure solvingto map the molecules that drive biology.

每周，Foldit 科学家会发布新的谜题，专注于蛋白质折叠的最新问题。继续阅读，了解蛋白质设计以治疗流感、COVID-19 等疾病的研究进展，小分子设计以发明新的药物化合物，以及蛋白质结构解析以绘制驱动生物学的分子图。

(Left) A protein designed by @Waya,@Galaxie, and@Susumeand (right) a crystal of this protein in the lab, ready for x-ray diffraction. This protein design was published inKoepnick et al. (2019)as Foldit1, and the solved structure is deposited in the PDB with ID6MRR.

（左）由@Waya、@Galaxie 和@Susume 设计的蛋白质，（右）实验室中该蛋白质的晶体，准备进行 X 射线衍射。该蛋白质设计在 Koepnick 等人（2019）的论文中作为 Foldit1 发表，其解析的结构已存入 PDB，ID 为 6MRR。

Protein Design 蛋白质设计

The living world is full of proteins that have evolved to carry out the amazing functions of biology, from digesting food to firing neurons. The goal of protein design is to create brand new proteins to carry out brand new functions. We'd like to design proteins that can shut down viruses like influenza, break down plastic, or self-assemble into new materials. 生命世界中充满了蛋白质，这些蛋白质已经进化出执行生物学中惊人的功能，从消化食物到激发神经元。蛋白质设计的目的是创造全新的蛋白质，以执行全新的功能。我们希望设计出能够关闭流感病毒、分解塑料或自我组装成新材料的新蛋白质。

The big challenge of protein design is that protein molecules must fold correctly all by themselves. If a protein is poorly designed and misfolds, then it cannot carry out its intended function. To try your hand at protein design, look for Foldit puzzles in the Design Category. 蛋白质设计的重大挑战在于蛋白质分子必须自行正确折叠。如果蛋白质设计不良并发生错误折叠，则无法执行其预定功能。想尝试蛋白质设计，请查找设计类别的 Foldit 谜题。

Small Molecule Design 小分子设计

Common medicines like aspirin are examples of non-protein small molecules. Even though these compounds are tiny, they can have a big impact on natural proteins in the body. Research in small molecule design aims to create new drug compounds to target disease-related proteins. 常用药物如阿司匹林是非蛋白质小分子的例子。尽管这些化合物很小，但它们可以对体内的天然蛋白质产生重大影响。小分子设计研究旨在创建新的药物化合物以针对疾病相关的蛋白质。

Small molecule design is difficult because the sheer number of possible molecules is overwhelming for a single design strategy. Crowdsourcing is a great way to use human creativity for diverse strategies and outside-the-box thinking. Help design new small molecule drugs by playing Foldit puzzles in the Small Molecule Design Category. 小分子设计困难，因为可能的分子数量庞大，对于单一的设计策略来说是压倒性的。众包是利用人类创造力进行多样化策略和跳出思维框框的绝佳方式。通过在 Small Molecule Design 类别中玩 Foldit 谜题来帮助设计新的小分子药物。

Structure Solving 结构解析

There are millions of different proteins in the natural world, and each one folds into a unique structure. Solving a protein's structure is essential to understand how the protein functions, and can lead researchers to new paths for treating disease. Since proteins are too small to see under a microscope, scientists use indirect methods to get clues about how each protein folds. We use those clues to solve the protein's structure. 自然界中有数百万种不同的蛋白质，每一种都会折叠成独特的结构。解决蛋白质的结构对于理解蛋白质的功能至关重要，并且可以引导研究人员找到治疗疾病的新途径。由于蛋白质太小，无法在显微镜下观察到，科学家们使用间接方法来获取有关蛋白质如何折叠的线索。我们利用这些线索来解决蛋白质的结构。

Foldit is especially useful for solving protein structures with electron density maps. These maps show the overall shape of a folded protein, although sometimes maps are noisy or difficult to interpret. Try out puzzles in the Electron Density Category to help scientists solve the structure of natural proteins. Foldit 特别适用于解决带有电子密度图的蛋白质结构。这些图显示了折叠蛋白质的整体形状，尽管有时图可能很嘈杂或难以解释。尝试在电子密度类别中的谜题，以帮助科学家解决天然蛋白质的结构。

两种模式 标准模式 教育模式

本文标签： Foldit